A DYNAMIC MULTI-TISSUE MODEL TO STUDY HUMAN METABOLISM

Abstract Metabolic modeling enables the study of human metabolism in healthy and in diseased conditions, e.g., the prediction of new drug targets and biomarkers for metabolic diseases.To accurately describe blood and urine metabolite dynamics, the integration of multiple metabolically active tissues is necessary.We developed a dynamic multi-tissue

Therapy for inflammatory bowel diseases (IBD) has developed during recent years.Despite the availability of new therapeutic modalities, overall therapy success remains modest, and complete remission is usually achieved and maintained in approximately 30% of patients only.This observation can be explained by a number of reasons.First, the involvemen